Enantioselective Synthesis of All‐Carbon Quaternary Stereogenic Centers by Catalytic Asymmetric Conjugate Additions of Alkyl and Aryl Aluminum Reagents to Five‐, Six‐, and Seven‐Membered‐Ring β‐Substituted Cyclic Enones

Abstract

Solution to pesky problems: Effective methods for catalytic asymmetric conjugate additions of alkyl and aryl aluminum reagents with unactivated β-substituted cyclopentenones are now available (see scheme). Transformations, promoted by chiral bidentate N-heterocyclic carbene (NHC) copper complexes derived from 1, give rise to all-carbon quaternary stereogenic centers. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2008/z802910_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.