Angewandte Chemie International Edition · 2008 · 174 citations · 35 references
EngineeringBioengineeringMolecular BiologyBiophotonicsBiosensorsPhotonicsDna BiosensorsFluorescence SpectroscopyNucleic Acid BiosensorsOptical BiosensingOptical BiosensorsPhotonic CrystalsDna Hybridization BiosensorsDna Hybridization DetectionFluorescence BiosensorsFluorescence Resonance Energy TransferHybridization DetectionOptical Signal AmplificationPhotonic Crystal BiosensorsSelectivity
A strong signal: A fluorescence resonance energy transfer (FRET)-based DNA hybridization detection method uses a photonic crystal to amplify the optical signal (see picture). Single-mismatch selectivity and a sensitivity of about 13.5 fM are achieved.
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Todd R. Golub, Donna K. Slonim, Pablo Tamayo et al. · Science · 1999 · 11.6K citations
Quantum Dot Bioconjugates for Ultrasensitive Nonisotopic Detection
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