Effects of Raloxifene After Tamoxifen on Breast and Endometrial Tumor Growth in Athymic Mice

Abstract

Raloxifene and tamoxifen had similar effects on these mouse models of tamoxifen-naive and tamoxifen-resistant breast and endometrial cancer. Treatment with raloxifene following 5 years of adjuvant tamoxifen may not further decrease breast cancer recurrence and may increase endometrial cancer incidence.