Synthesis of α‐Alkynyl‐β,β,β‐trifluoroalanine Derivatives by Sonogashira Cross‐Coupling Reaction

Abstract

Abstract An efficient route to new α‐CF 3 ‐α‐amino acid derivatives bearing an arylalkynyl moiety at the α‐carbon atom has been developed. The method is based on palladium‐catalyzed cross‐coupling of the corresponding α‐propargyl (ethynyl) α‐amino esters with aryl halides to afford the amino acid derivatives with an internal triple bond that is suitable for further modifications.