Nickel-Catalyzed Cross-Coupling of Aryl Chlorides with Aryl Grignard Reagents

Abstract

The ambient temperature Grignard cross-coupling of aryl chlorides with aryl magnesium halides [Eq. (1)] is made possible for the first time by nickel catalysts containing bulky N-heterocyclic carbene or bulky phosphane ligands. A 19F NMR spectroscopic screening assay with fluorinated aryl chlorides was employed to achieve a rapid identification and optimization of high-performance catalysts. acac = acetylacetonate. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2000/z14437_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.