A comparison of commonly used polyethoxylated pharmaceutical excipients on their ability to inhibit P‐glycoprotein activity in vitro

Characterization of the Human Colon Carcinoma Cell Line (Caco-2) as a Model System for Intestinal Epithelial Permeability

Ismael J. Hidalgo, Thomas J. Raub, Ronald T. Borchardt · Gastroenterology · 1989 · 2.2K citations

Life Sciences, Cell Biology, Oncology +14

MDCK (Madin-Darby Canine Kidney) Cells: A Tool for Membrane Permeability Screening

Jennifer D. Irvine, Lori H. Takahashi, Karen Lockhart et al. · Journal of Pharmaceutical Sciences · 1999 · 976 citations

Life Sciences, Biochemistry, Cell Biology +13

Caco-2 Cell Monolayers as a Model for Drug Transport Across the Intestinal Mucosa

Allen R. Hilgers, Robert A. Conradi, Philip S. Burton · Pharmaceutical Research · 1990 · 582 citations

Pharmacy, Pharmaceutics, Pharmacology +15

Mass transport Phenomena and Models: Theoretical Concepts

G.L. Flynn, Samuel H. Yalkowsky, T.J. Roseman · Journal of Pharmaceutical Sciences · 1974 · 516 citations

Engineering, Chemical Engineering, Physics +14

A retrovirus carrying an MDR1 cDNA confers multidrug resistance and polarized expression of P-glycoprotein in MDCK cells.

Ira Pastan, Michael M. Gottesman, Kazumitsu Ueda et al. · Proceedings of the National Academy of Sciences · 1988 · 491 citations · Full text

Life Sciences, Microbiology, Pharmacology +11