Concepedia

Highly Antimalaria‐Active Artemisinin Derivatives: Biological Activity Does Not Correlate with Chemical Reactivity

Richard K. Haynes, Wing‐Yan Ho, Ho‐Wai Chan, Burkhard Fugmann, Jörg Stetter, Simon L. Croft, Livia Vivas, Wallace Peters, B. L. Robinson

Angewandte Chemie International Edition · 2004 · 146 citations · 48 references

DOI

Concepts

Abstract

New leads for antimalarial drugs? 10-Alkylaminoartemisinin derivatives like that shown display in vivo antimalarial activities greater than those of the parent artemisinin. Previous conclusions regarding the chemical basis for the antimalarial activity of these compounds must be reconsidered.

References

48

Artemisinins target the SERCA of Plasmodium falciparum

Ursula Eckstein‐Ludwig, Richard Webb, Iris D. A. van Goethem et al. · Nature · 2003 · 1K citations

, , +12

Antimalarial drug resistance and combination chemotherapy

Nicholas J. White · Philosophical Transactions of the Royal Society B Biological Sciences · 1999 · 478 citations

, , +17

Artemisinin and the antimalarial endoperoxides: from herbal remedy to targeted chemotherapy.

Steven R. Meshnick, Terrie E. Taylor, Sumalee Kamchonwongpaisan · Microbiological Reviews · 1996 · 291 citations · Full text

, , +17

Plasmodium falciparum: In Vitro Studies of the Pharmacodynamic Properties of Drugs Used for the Treatment of Severe Malaria

Nicholas J. White, PAH Holloway, Geoffrey Pasvol et al. · Experimental Parasitology · 1993 · 289 citations

, , +17

The Plasmodium falciparum Translationally Controlled Tumor Protein Homolog and Its Reaction with the Antimalarial Drug Artemisinin

Jamaree Bhisutthibhan, Xing-Qing Pan, Paul A. Hossler et al. · Journal of Biological Chemistry · 1998 · 256 citations · Full text

, , +15