Hydroxyphenyl‐1‐methylpyridinium‐jodide als potentielle Reaktivatoren von mit Organophosphor‐Verbindungen vergifteten Acetylcholinesterasen

Abstract

Hydroxyphenyl‐1‐methylpyridinium‐iodide as Potential Reactivators of Acetylcholinesterase Poisoned with Organophosphorus Compounds . It was our aim to reactivate acetylcholinesterase poisoned with sarin. We synthesized 2‐( o ‐hydroxyphenyl)‐1‐methylpyridinium‐iodide ( 9 ), 2‐( p ‐hydroxyphenyl)‐1‐methylpyridinium‐iodide ( 19 ) and 4‐( o ‐hydroxyphenyl)‐1‐methylpyridinium‐iodide ( 14 ) as potential reactivators. All substances showed moderate toxicity against mice; their reactivity potency in vitro and in vivo was negligible.