In chronic idiopathic urticaria autoantibodies against FcɛRII/CD23 induce histamine release via eosinophil activation

Abstract

Our results indicate that patients with chronic idiopathic urticaria have Abs against CD23 and that eosinophils, which infiltrate the skin of these patients, play a crucial role in maintaining the disease through the release of major basic protein upon engagement of the low-affinity IgE receptor by such auto-Abs.