Presynaptic Prostaglandin E₂EP₁-Receptor Facilitation of Cerebral Nitrergic Neurogenic Vasodilation

Abstract

These results suggest that neuronal PGE(2) facilitates nitric oxide release from the cerebral perivascular parasympathetic nitrergic nerve terminals by increasing neuronal calcium influx through activation of presynaptic EP(1) receptors. PGE(2) may play an important role in regulating the nitrergic neurovascular transmission in the cerebral circulation.