Autocrine and Paracrine Function of Angiotensin 1-7 in Tissue Repair During Hypertension

Abstract

ACE2 and MasR expressions in the hypertensive heart and kidney are not regulated by circulating AngII levels. Ang1-7 is involved in multiple repair responses, suggesting that therapeutic strategies aimed at administering Ang1-7 hold potential for the management of cardiac remodeling.