The reaction of (<i>N</i>‐isocyanimino) triphenylphosphorane with an electron‐poor α‐haloketone in the presence of aromatic carboxylic acids: A novel three‐component reaction for the synthesis of disubstituted 1,3,4‐oxadiazole derivatives

Abstract

Abstract Reactions of electron‐poor α‐haloketones with ( N ‐isocyanimino) triphenylphosphorane in the presence of aromatic carboxylic acids proceed smoothly at room temperature and in neutral conditions to afford disubstituted 1,3,4‐oxadiazole derivatives in high yields. © 2010 Wiley Periodicals, Inc. Heteroatom Chem 21:368–372, 2010; View this article online at wileyonlinelibrary.com . DOI 10.1002/hc.20626