Publication | Closed Access
An Improved Copper‐Mediated Oxidative Trifluoromethylation of Terminal Alkynes
50
Citations
24
References
2011
Year
Terminal AlkynesChemical EngineeringRoom TemperatureEngineeringCross-coupling ReactionFluorous SynthesisOrganic ChemistryOrganometallic CatalysisChemistryTmscf 3
Abstract An improved method for the efficient copper‐mediated trifluoromethylation of terminal alkynes has been developed. This protocol highlights the convenient access to a variety of aryl‐substituted trifluoromethylated alkynes by oxidative trifluoromethylation with two equivalents of TMSCF 3 at room temperature.
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