Inhibition of Hydroxyapatite Nanoparticle‐Induced Osteogenic Activity in Skeletal Cells by Adsorption of Serum Proteins

Abstract

Stimulation of osteogenesis in human bone marrow stromal cells by surface attachment and endocytosis of arginine-functionalized hydroxyapatite nanoparticles is enhanced when serum proteins are omitted from the culture medium for an initial 24 hour period. This effect, which is related to nanoparticle binding of the serum proteins, could be an important consideration in nanoparticle-induced bioactivity and nanotoxicity in general. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.