PubMed · 2014 · 49 citations · 17 references
ComputingBioinformaticsComputer ScienceComputational BiologyMachine LearningOptimizationBiological NetworksGraph AnalyticsGraph-based LearningNetwork InferenceNetwork ModelingAlternating Direction Method Of MultipliersColumn OverlapConvex RelaxationsGaussian Graphical ModelsGraphical Model LearningGraphical ModelsHub NodesIsing Model
penalty implicitly assumes that each edge is equally likely and independent of all other edges. We propose a general framework to accommodate more realistic networks with hub nodes, using a convex formulation that involves a row-column overlap norm penalty. We apply this general framework to three widely-used probabilistic graphical models: the Gaussian graphical model, the covariance graph model, and the binary Ising model. An alternating direction method of multipliers algorithm is used to solve the corresponding convex optimization problems. On synthetic data, we demonstrate that our proposed framework outperforms competitors that do not explicitly model hub nodes. We illustrate our proposal on a webpage data set and a gene expression data set.
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Emergence of Scaling in Random Networks
Albert-Ĺaszló Barabási, Réka Albert · Science · 1999 · 36.4K citations · Full text
Roel G.W. Verhaak, Katherine A. Hoadley, Elizabeth Purdom et al. · Cancer Cell · 2010 · 7.7K citations · Full text
Lethality and centrality in protein networks
Hawoong Jeong, S. P. Mason, Albert-Ĺaszló Barabási et al. · Nature · 2001 · 5.4K citations · Full text