Publication | Closed Access
A Stable Homodinuclear Biscobalt(III)–Schiff Base Complex for Catalytic Asymmetric 1,4‐Addition Reactions of β‐Keto Esters to Alkynones
130
Citations
20
References
2009
Year
EngineeringOrganic ChemistryChemistryChemical EngineeringCatalytic Asymmetric 1,4‐AdditionOrganometallic CatalysisMoisture SensitivityInorganic ChemistryCross-coupling ReactionCatalysisAsymmetric CatalysisEnantioselective SynthesisBiomolecular EngineeringAsymmetric 1,4-AdditionStable Homodinuclear BiscobaltAlkene MetathesisMetal Cooperation–Schiff Base ComplexSynthetic Chemistry
Two metal cooperation: A homodinuclear Co(2)-Schiff base complex Co(2)(OAc)(2)-1 promoted the asymmetric 1,4-addition of beta-keto esters to alkynones under solvent-free conditions in air (see scheme). The reactions proceeded without air or moisture sensitivity in high yields and with high enantioselectivities (99-91% ee) at room temperature under highly concentrated conditions (neat-20 M) with 0.1-2.5 mol % catalyst loading.
| Year | Citations | |
|---|---|---|
Page 1
Page 1