Concepedia

Histone H3 lysine 27 acetylation is altered in colon cancer

Jakub Karczmarski, Tymon Rubel, Agnieszka Paziewska, Mateusz Bujko, Paulina Kober, Michał Dadlez, Jerzy Ostrowski

Clinical Proteomics · 2014 · 118 citations · 34 references

DOIFull text

Open access

Abstract

The present results indicate the usefulness of a bottom-up proteomic approach for the detection of histone modifications at a global scale. The differential abundance of H3K27Ac mark in CRC, a PTM associated with active enhancers, suggests its role in regulating genes whose expression changes in CRC.

References

34

An integrated encyclopedia of DNA elements in the human genome

Nature · 2012 · 18.9K citations · Full text

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Histone H3K27ac separates active from poised enhancers and predicts developmental state

Menno P. Creyghton, Albert W. Cheng, G. Grant Welstead et al. · Proceedings of the National Academy of Sciences · 2010 · 4.4K citations · Full text

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An integrated encyclopedia of DNA elements in the human genome

Ian Dunham, Anshul Kundaje, Shelley Force Aldred et al. · The Journal of the American Medical Association (JAMA) Network (American Medical Association) · 2012 · 2.8K citations · Full text

Combinatorial patterns of histone acetylations and methylations in the human genome

Zhibin Wang, Chongzhi Zang, Jeffrey Rosenfeld et al. · Nature Genetics · 2008 · 2.3K citations · Full text

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A unique chromatin signature uncovers early developmental enhancers in humans

Álvaro Rada-Iglesias, Ruchi Bajpai, Tomek Swigut et al. · Nature · 2010 · 2.3K citations · Full text

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