Enantioselective organocatalytic phospha-Michael reaction of α,β-unsaturated ketones

Abstract

Enantioselective organocatalytic phospha-Michael reaction of alpha,beta-unsaturated ketones and diaryl phosphine oxides has been developed for the first time employing multifunctional organocatalysts. Optically active products bearing quaternary chiral carbon stereocenters were obtained in high yields with good to excellent enantioselectivities (up to 98% ee).