Rapid Multiphase Carbonylation Reactions by Using a Microtube Reactor: Applications in Positron Emission Tomography ¹¹C‐Radiolabeling

Abstract

Taking the tube: A silica-supported palladium catalyst packed into teflon tubing is a simple, low-cost, and effective method for carrying out carbonylative cross-coupling reactions of arylhalides with amines and radiolabeled carbon monoxide gas. In carbonylation reactions, the microtube reactor displays enhanced yields over a short time period (12 min) compared with batch methods.