A Facile One‐Pot Transformation of Baylis–Hillman Adducts into Unsymmetrical Disubstituted Maleimide and Maleic Anhydride Frameworks: A Facile Synthesis of Himanimide A

Abstract

Unsymmetrical, disubstituted maleimide and maleic anhydride frameworks have been accessed from Baylis–Hillman adducts in an operationally simple three-step (Friedel–Crafts reaction, selective hydrolysis, and cyclization), one-pot strategy. This strategy has been successfully extended to the synthesis of a representative bioactive compound, himanimide A (see scheme). Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.