Structural Characterization of Backbone‐Expanded Helices in Hybrid Peptides: (αγ)_<i>n</i> and (αβ)_<i>n</i> Sequences with Unconstrained β and γ Homologues of <scp>L</scp>‐Val

Abstract

Learning your αβγ′s: The diversity of hydrogen-bonding patterns in backbone-expanded hybrid helices is shown by crystal-structure determination of several oligomeric peptides (see scheme; C=gray; H=white; O=red; N=blue). C12 helices were observed in the αγ peptide series for n=2–8. In comparison, the αα peptide and αβ peptide sequences show C10 and mixed C14/C15 helices, respectively. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.