Concepedia

Epoxomicin, a new antitumor agent of microbial origin.

Minoru Hanada, Koko Sugawara, KEIKO KANETA, SOICHIRO TODA, Yuji Nishiyama, Koji Tomita, Haruaki Yamamoto, MASATAKA KONISHI, TOSHIKAZU OKI

The Journal of Antibiotics · 1992 · 213 citations · 4 references

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Abstract

An actinomycete strain No. Q996-17 produced a novel compound, epoxomicin, which exhibited in vivo antitumor activity against B16 melanoma. Structural studies indicated that it is a new member of the epoxy-beta-aminoketone group, and is closely related to eponemycin.

References

4

Bergey's Manual of Systematic Bacteriology

Annals of Internal Medicine · 1990 · 15.7K citations

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Eponemycin, a new antibiotic active against B16 melanoma. I. Production, isolation, structure and biological activity.

Koko Sugawara, Masami Hatori, Yuji Nishiyama et al. · The Journal of Antibiotics · 1990 · 104 citations · Full text

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Eponemycin, a novel antibiotic, is a highly powerful angiogenesis inhibitor

Tsutomu Oikawa, Masami Hasegawa, Mariko Shimamura et al. · Biochemical and Biophysical Research Communications · 1991 · 54 citations

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BMY-28438 (3,7-dihydroxytropolone), a new antitumor antibiotic active against B16 melanoma. I. Production, isolation, structure and biological activity.

Koko Sugawara, MASARU OHBAYASHI, Keiko Shimizu et al. · The Journal of Antibiotics · 1988 · 35 citations · Full text

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