Trials · 2015 · 78 citations · 23 references
MedicinePerioperative MedicineSurgeryIron Metabolism DisordersPerioperative Outcomes ResearchTransfusion MedicineAnemiaBlood Transfusion ManagementIron Chelation TherapyIron DeficiencyPerioperative Blood ManagementPreoperative Risk AssessmentBlood Transfusion ReductionBlood Transfusion TherapyClinicaltrials.gov RegistrationHospital Stay DurationIntravenous Iron AdministrationPreoperative Anemia ManagementRecovery After Major SurgeryTransfusion In Anemia Management
BACKGROUND: Anaemia is common in patients undergoing major surgery. The current standard of care for patients with low haemoglobin in the peri-operative period is blood transfusion. The presence of preoperative anaemia is associated with an increased likelihood of the patient receiving peri-operative transfusion and worsened outcomes following surgery, more post-operative complications, delayed recovery and greater length of hospital stay. Intravenous iron, if applied in the preoperative setting, may correct anaemia by the time of surgery and reduce the need for blood transfusion and improve outcomes. METHODS/DESIGN: PREVENTT is a phase III double-blind randomised controlled trial that will compare the use of intravenous ferric carboxymaltose (dose 1000 mg) with placebo 10-42 days before major open abdominal surgery in 500 patients with anaemia (haemoglobin < 120 g/L). The primary outcome measure will be the need for blood transfusion and secondary endpoints will include post-operative recovery, length of hospital stay, health care utilisation and cost analysis. TRIAL REGISTRATION: ISRCTN67322816--registered 9 October 2012. ClinicalTrials.gov identifier: NCT01692418.
23
Liberal or Restrictive Transfusion in High-Risk Patients after Hip Surgery
Jeffrey L. Carson, Michael L. Terrin, Helaine Noveck et al. · New England Journal of Medicine · 2011 · 1.3K citations · Full text