High Daily Dose and Being a Substrate of Cytochrome P450 Enzymes Are Two Important Predictors of Drug-Induced Liver Injury

Acute liver failure

William M. Lee, Robert H. Squires, Scott L. Nyberg et al. · Hepatology · 2008 · 754 citations · Full text

Medicine, Clinical Sciences, Internal Medicine +15

Sex Is A Major Determinant of Cyp3a4 Expression in Human Liver

Renzo Wolbold, Kathrin Klein, Oliver Burk et al. · Hepatology · 2003 · 510 citations · Full text

Medicine, Pharmacology, Toxicology +13

Liver transplantation for acute liver failure from drug induced liver injury in the United States

Mark W. Russo, Joseph A. Galanko, Roshan Shrestha et al. · Liver Transplantation · 2004 · 483 citations

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FDA-approved drug labeling for the study of drug-induced liver injury

Minjun Chen, Vikrant Vijay, Qiang Shi et al. · Drug Discovery Today · 2011 · 409 citations

Pharmacy, Pharmacology, Toxicology +14

Effect of St John's Wort on Drug Metabolism by Induction of Cytochrome P450 3A4 Enzyme

John S. Markowitz · JAMA · 2003 · 400 citations

Medicine, Pharmacokinetics, Pharmacology +17