An Efficient Total Synthesis of (±)-Galanthamine

Abstract

Intramolecular Heck reaction of 3 generates a spiro quaternary C atom—a key step in an efficient synthesis of galanthamine (1). Galanthamine can be readily obtained from the spiro tricyclic dienone 2, which was prepared by nonclassical dehydrogenation of the corresponding α,β-unsaturated ketone.