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Preparation of 2,4-Dihydroxybenzaldehyde by the Vilsmeier-Haack Reaction
37
Citations
4
References
1996
Year
EngineeringHeterocyclicNatural SciencesDiversity-oriented SynthesisOrganic ChemistryIntermediate Formamidinium SaltsChemistryOxalyl Chloride/dmfVilsmeier-haack ReactionHeterocycle ChemistrySynthesis MethodSynthetic ChemistryBiomolecular EngineeringNatural Product Synthesis
Abstract An efficient synthesis of 2,4-dihydroxybenzaldehyde (1) from resorcinol via the Vilsmeier-Haack reaction has been developed. Either phosphorous oxychloride/DMF or oxalyl chloride/DMF produces 1 in yields of 65–75%. The intermediate formamidinium salts have been characterized.
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