Matrix Metalloproteinase‐2 Negatively Regulates Cardiac Secreted Phospholipase A ₂ to Modulate Inflammation and Fever

Abstract

A heart-centric MMP-2/sPLA2 axis may modulate blood pressure homeostasis, inflammatory and metabolic gene expression, and the severity of fever. This discovery helps researchers to understand the cardiovascular and systemic effects of MMP-2 inhibitors and suggests a disease mechanism for human MMP-2 gene deficiency.