Archives of Internal Medicine · 1986 · 550 citations · 28 references
Life SciencesHematologyObstetricsAutoimmunityClinical ImmunologyMaternal-fetal MedicineAntibody ScreeningAutoantibodiesAutoimmune BiomarkersAutoimmune Disease DiagnosticsAutoimmune DiseasesAutoimmune Hematologic DiseaseAnticardiolipin AntibodiesAutoimmune Reproductive DisordersMaternal Autoimmune DiseasePositive Predictive ValuePositive Predictive Value EstimationThrombocytopenia In PregnancyThrombosis PathophysiologyUnexplained Recurrent Pregnancy Loss
To determine the predictive value of the IgG anticardiolipin antibody (ACA) test for thrombosis, recurrent fetal loss, and thrombocytopenia, the clinical features of 121 patients with varying antibody levels were studied. When patients were grouped into high-positive, low-positive, and normal groups according to their ACA levels, there were strong statistical correlations with arterial thrombosis, venous thrombosis, fetal loss, thrombocytopenia, and a positive Coombs' test. At levels of 7 SD and above, the test was highly specific (greater than 80%) and predictive (greater than 70%) for thrombosis, thrombocytopenia, and recurrent fetal loss. This study suggests that the IgG ACA test may be a useful predictor for thrombosis, recurrent fetal loss, and thrombocytopenia in patients with autoimmune disorders.
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The 1982 revised criteria for the classification of systemic lupus erythematosus
Eng M. Tan, Alan S. Cohen, James F. Fries et al. · Arthritis & Rheumatism · 1982 · 14.6K citations
Gordon C. Sharp, William S. Irvin, Eng M. Tan et al. · The American Journal of Medicine · 1972 · 1.8K citations