Identification of the route of action of the carcinogen 3:2-dimethyl-4-aminobiphenyl in the induction of intestinal neoplasia.

Abstract

Wistar rats were used in the identification of the route of action in the induction of intestinal neoplasia by the carcinogen 3:2′-dimethyl-4-aminobiphenyl. By operative manipulation, segments of the rat colon were defunctionalized and fecal contact with intestinal mucosa was minimized. Rats were given the carcinogen in a convenient dosage schedule, and neoplasia was induced. Interpretation of these experiments suggests that the chemical is absorbed from the injection site; modified, probably in the liver; excreted into the bile; and neoplasia induced by direct contact of feces with the intestinal mucosal cell.