Laterally Resolved and Direct Spectroscopic Evidence of Nanometer‐Sized Lipid and Protein Domains on a Single Cell

Abstract

Tip-enhanced Raman spectroscopy is used as a label-free, nondestructive method for the direct mapping of nano­meter-sized lipid and protein domains on the surface of a single cell (see graphic). Spectral unmixing allows the analysis and visualization of the different cellular surface components down to a spatial resolution of 10–20 nm. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.