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INHIBITION OF 5′‐NUCLEOTIDASE IN RAT BRAIN BY METHYLXANTHINES
45
Citations
6
References
1975
Year
Camp PhosphodiesterasePharmacotherapyExperimental PharmacologySocial SciencesMolecular PharmacologyNeurochemistryInhibitory ActivityMolecular NeuroscienceSimilar InhibitionBiochemistryInhibition Of 5′‐NucleotidaseNeuropharmacologyNeuroprotectionPharmacologyEc 3.1.3.5NeurophysiologyNeuroscienceMolecular NeurobiologyMedicine
Abstract —Rat brain 5′‐nucleotidase (EC 3.1.3.5) is inhibited by methylxanthines such as theophylline. Inhibition of the 5′‐nucleotidase by theophylline appears more efficient than the inhibition of cAMP phosphodiesterase by this drug. A similar inhibition is observed with caffeine, theobromine, 7′‐methyl‐xanthine and 1‐methylxanthine.
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