Green Synthesis of Aminobisphosphonates Under Microwave Irradiation

Abstract

Abstract A simple, efficient, and environmentally benign green chemical method has been developed for the synthesis of aminobisphosphonates by reacting aliphatic/aromatic 2°-amines, dimethylphosphite, and triethylorthoformate by microwave irradiation under solvent-free conditions, in the presence of an alumina solid support. The advantages of this method are less reaction time, simple work-up, and excellent yields. Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file. GRAPHICAL ABSTRACT