Glycocoating of Oligovalent Amines: Synthesis of Thiourea‐Bridged Cluster Glycosides from Glycosyl Isothiocyanates

Abstract

Sugar coating for dendrimers! Glycosyl isothiocyanates react with polyamidoamine dendrimers as core units to form glycoconjugates containing many sugar moieties (schematic representation of clustering of mannose residues shown on the right), which function as antiadhesives in cell – cell recognition. This flexible, speedy preparation can generate diverse cluster glycosides on a gram scale.