Gold Nanoparticles Presenting Hybridized Self‐Assembled Aptamers That Exhibit Enhanced Inhibition of Thrombin

Abstract

DNA hybridization of thrombin-binding aptamers (TBAs) to form a self-assembled arranged monolayer on gold nanoparticles (Au NPs) was used to control the coagulation activity of thrombin. The hTBA15/hTBA29/cDNA-Au NPs provided flexibility and a suitable orientation and distance between the hTBA15 and hTBA29 units for bivalent binding, allowing strong interactions with thrombin and extremely high anticoagulant potency. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.