Extended survival of a HER-2-positive metastatic breast cancer patient with brain metastases also treated with intrathecal trastuzumab

Use of Chemotherapy plus a Monoclonal Antibody against HER2 for Metastatic Breast Cancer That Overexpresses HER2

Dennis J. Slamon, Brian Leyland‐Jones, Steven Shak et al. · New England Journal of Medicine · 2001 · 11.5K citations · Full text

Medicine, Oncology, Pharmacology +10

Lapatinib plus Capecitabine for HER2-Positive Advanced Breast Cancer

Charles E. Geyer, John Forster, Deborah Lindquist et al. · New England Journal of Medicine · 2006 · 3.5K citations · Full text

Medicine, Oncology, Pharmacology +17

Central nervous system metastases in women who receive trastuzumab‐based therapy for metastatic breast carcinoma

Johanna C. Bendell, Susan M. Domchek, Harold J. Burstein et al. · Cancer · 2003 · 1.3K citations

Medicine, Neurology, Oncology +17

Ratio of trastuzumab levels in serum and cerebrospinal fluid is altered in HER2-positive breast cancer patients with brain metastases and impairment of blood–brain barrier

Hans‐Joachim Stemmler, Manfred Schmitt, Amina Willems et al. · Anti-Cancer Drugs · 2006 · 411 citations

Medicine, Oncology, Pharmacology +17

Incidence of cerebral metastases in patients treated with trastuzumab for metastatic breast cancer

Alison Clayton, Sarah Danson, Sanjay Jolly et al. · British Journal of Cancer · 2004 · 385 citations · Full text

Medicine, Neurology, Oncology +17