Azumamides A–E: Histone Deacetylase Inhibitory Cyclic Tetrapeptides from the Marine Sponge <i>Mycale izuensis</i>

Abstract

A zoom in on azumamides (1): Azumamides A–E are five new cyclic tetrapeptides isolated from the marine sponge Mycale izuensis. The azumamides display inhibitory activity toward histone deacetylase with IC50 values of 0.045–1.3 μg mL−1. Their structures were determined on the basis of spectroscopic analysis and chemical degradation. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2006/z602047_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.