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PdII-Catalyzed Cyclization of Alkynes Containing Aldehyde, Ketone, or Nitrile Groups Initiated by the Acetoxypalladation of Alkynes
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2002
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Chemical EngineeringAlkynes Containing AldehydeEngineeringCross-coupling ReactionAlkene MetathesisNatural SciencesPdii-catalyzed SystemDiversity-oriented SynthesisCarbon–palladium BondNitrile Groups InitiatedOrganic ChemistryOrganometallic CatalysisCatalysisChemistryPdii-catalyzed CyclizationNitrile UnitsAsymmetric Catalysis
The insertion of carbonyl or nitrile units into a carbon–palladium bond has been achieved under mild reaction conditions (see scheme). The PdII-catalyzed system, which does not require organometallic reagents, redox systems, or additives to obtain a high yield of cyclized product, is effective with a wide variety of functionalized alkyne compounds.