Emerging infectious diseases · 2006 · 183 citations · 27 references
Veterinary MedicineInfectious Disease ControlInfectious DiseasesEpidemiologyInfectious Disease EpidemiologySpatial EpidemiologyDisease Risk AssessmentEntomological Risk AssessmentEpidemiology Of Insect DiseasesTransmission DynamicsVector-borne Disease SurveillanceVector-borne TransmissionAedes Aegypti TransmissionCase-control Study DesignDengue FeverMosquito-borne Disease EpidemiologyMosquito-borne Disease OutbreaksMosquito-borne Disease RiskMosquito-borne Disease SurveillanceTransmission Risk Analysis
We assessed in a case-control study the test-validity of Aedes larval indices for the 2000 Havana outbreak. "Cases" were blocks where a dengue fever patient lived during the outbreak. "Controls" were randomly sampled blocks. Before, during, and after the epidemic, we calculated Breteau index (BI) and house index at the area, neighborhood, and block level. We constructed receiver operating characteristic (ROC) curves to determine their performance as predictors of dengue transmission. We observed a pronounced effect of the level of measurement. The BI(max) (maximum block BI in a radius of 100 m) at 2-month intervals had an area under the ROC curve of 71%. At a cutoff of 4.0, it significantly (odds ratio 6.00, p<0.05) predicted transmission with 78% sensitivity and 63% specificity. Analysis of BI at the local level, with human-defined boundaries, could be introduced in control programs to identify neighborhoods at high risk for dengue transmission.
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Dana A. Focks, Richard J. Brenner, Jack P. Hayes et al. · American Journal of Tropical Medicine and Hygiene · 2000 · 408 citations