Complex Trait Analysis of Ventricular Septal Defects Caused by <i>Nkx2-5</i> Mutation

Abstract

Enumerable factors contribute to the presentation of a congenital heart defect. The factors that modify rather than cause congenital heart disease substantially affect risk in predisposed individuals. Their characterization in a mouse model offers the potential to narrow the search space in human studies and to develop alternative strategies for prevention.