Angewandte Chemie International Edition · 2009 · 155 citations · 24 references
PharmacyCell BiologyPharmaceuticsDrug DeliveryEndocytosisIntracellular TransportCellular UptakeDrug EncapsulationNanocarriers For TherapeuticsNanomaterials For Drug DeliveryNanoparticle Delivery SystemsNanoparticle DesignDrug Delivery NanocarriersFluorescent DyesNanocarrier Uptake MechanismsNanocarriersScavenger Receptor-mediated UptakeSchematic Representation
Getting straight to the point: A peptide–phospholipid-based biomimetic nanocarrier was developed that can transport cargo molecules directly into cytosolic compartments through a non-endocytotic uptake mechanism mediated by scavenger receptor class B type I (SR-BI; see schematic illustration). The fluorescent image shows the cytosolic localization of a dye (red) delivered by the nanocarrier to SR-BI-positive cells (nuclei: blue, membranes: cyan).
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