Concepedia

An Efficient One‐Pot Synthesis of Dihydropyrimidinones by a Samarium Diiodide Catalyzed Biginelli Reaction Under Solvent‐Free Conditions

Xiaoyan Han, Fan Xu, Yiqin Luo, Qi Shen

European Journal of Organic Chemistry · 2005 · 65 citations · 25 references

DOI

Concepts

Abstract

Abstract The Biginelli reaction, a one‐pot condensation of aldehydes, urea or thiourea, and β‐dicarbonyl compounds, is efficiently catalyzed by samarium diiodide. The biologically active dihydropyrimidinones are easily synthesized in moderate to excellent yields under solvent‐free conditions. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)

References

25

Lanthanide Triflate Catalyzed Biginelli Reaction. One-Pot Synthesis of Dihydropyrimidinones under Solvent-Free Conditions

Yun Ma, Changtao Qian, Limin Wang et al. · The Journal of Organic Chemistry · 2000 · 518 citations

, , +5

Unprecedented Catalytic Three Component One-Pot Condensation Reaction:  An Efficient Synthesis of 5-Alkoxycarbonyl- 4-aryl-3,4-dihydropyrimidin-2(1H)-ones

Essa Hu, Daniel R. Sidler, Ulf‐H. Dolling · The Journal of Organic Chemistry · 1998 · 501 citations

, , +6

Indium(III) Chloride-Catalyzed One-Pot Synthesis of Dihydropyrimidinones by a Three-Component Coupling of 1,3-Dicarbonyl Compounds, Aldehydes, and Urea: An Improved Procedure for the Biginelli Reaction

Brindaban C. Ranu, Alakananda Hajra, Umasish Jana · The Journal of Organic Chemistry · 2000 · 474 citations

, , +5

Conformational analysis of 4-aryl-dihydropyrimidine calcium channel modulators. A comparison of ab initio, semiempirical and X-ray crystallographic studies

C. Oliver Kappe, Walter M. F. Fabian, M.A. Semones · Tetrahedron · 1997 · 402 citations

, , +17

Substituted 1,4-dihydropyrimidines. 3. Synthesis of selectively functionalized 2-hetero-1,4-dihydropyrimidines

Karnail S. Atwal, George C. Rovnyak, Brian C. O'Reilly et al. · The Journal of Organic Chemistry · 1989 · 365 citations

, , +9