Relevant Anion–π Interactions in Biological Systems: The Case of Urate Oxidase

Abstract

Enzyme inhibited: The important role of anion–π interactions that are present in the active site of the urate oxidase enzyme is reported (see picture). The inhibition of this enzyme by cyanide ions is caused by the existence of an anion–π interaction between the inhibitor and the enzymatic substrate. This investigation extends the relevance of anion–π interactions to important fields such as enzyme chemistry. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.