Association of Type 2 Diabetes Candidate Polymorphisms in <i>KCNQ1</i> With Incretin and Insulin Secretion

Abstract

Common genetic variation in KCNQ1 is associated with insulin secretion upon oral glucose load in a German population at increased risk of type 2 diabetes. The discrepancy between orally and intravenously administered glucose seems to be explained not by altered incretin signaling but most likely by changes in incretin secretion.