Publication | Closed Access
[N‐methyl‐<sup>11</sup>C]‐scopolamine: Synthesis and distribution in rat brain
41
Citations
12
References
1983
Year
Sodium CyanoborohydrideNeurotransmitterPsychopharmacologyReductive MethylationPharmacotherapyExperimental PharmacologySocial SciencesRat BrainMolecular PharmacologyNeurochemistryMolecular NeuroscienceMuscarine Receptor PopulationNeuropharmacologyDopaminePharmacologyDopamine ResearchNeurophysiologyNeuroanatomyMonoamine NeurotransmittersNeuroscienceMolecular NeurobiologyMedicine
Abstract The muscarinic antagonist [N‐methyl‐ 11 C]‐scopolamine was synthesized by reductive methylation of norscopolamine with H 11 CHO and sodium cyanoborohydride, and then purified using preparative high performance liquid chromatography (HPLC). Preliminary in vivo studies in rat suggest the distribution of this compound to parallel with the muscarine receptor population in the brain.
| Year | Citations | |
|---|---|---|
Page 1
Page 1