A 2-Helix Small Protein Labeled with ⁶⁸Ga for PET Imaging of <i>HER2</i> Expression

Abstract

This proof-of-concept research clearly demonstrated that synthetic 2-helix (68)Ga-DOTA-MUT-DS is a promising PET probe for imaging HER2 expression in vivo. The Affibody-derived small 2-helix protein scaffold has great potential for developing targeting agents for a variety of tumor-associated biomarkers.