A Small Molecule Targeting the Multifactorial Nature of Alzheimer's Disease

Abstract

Sights set on a cure: Memoquin (1) affects several mechanisms relevant to Alzheimer's disease (AD): the formation of reactive oxygen species, the processing and aggregation of amyloid β (Aβ) peptides, and acetylcholinesterase activity. In animal models, 1 causes a remarkable decrease in the formation of AD neurodegenerative hallmarks and a significant reversal of behavioral deficits. hAChE, BACE-1, and NQO1 are enzymes targeted by 1. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2007/z700256_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.