Bioorganogermanium Chemistry: Studies on C/Si/Ge Bioisosterism

Abstract

Abstract In context with systematic investigations on C/Si/Ge bioisosterism, the following studies were carried out: (a) synthesis and pharmacological characterization of centrochiral enantiomerically pure germanium-based muscarinic antagonists; (b) synthesis and pharmacological characterization of a germanium-containing decapeptide; (c) studies on the metabolism of a germanium-based drug in the rat; (d) synthesis of centrochiral enantiomerically pure germanes using biotransformations with whole microorganisms or isolated enzymes. These investigations demonstrated that there are distinct bioisosteric relationships between the C/Si/Ge analogues studied. Keywords:: bioorganogermanium chemistryC/Si/Ge bioisosterismsila-and germa-drugssilicon- and germanium-containing α-amino acids and peptidesmetabolism of sila- and germa-drugsstereoselective biocatalysis