Concepedia

Peroxisome Proliferator–Activated Receptor-γ Coactivator-1α Overexpression Increases Lipid Oxidation in Myocytes From Extremely Obese Individuals

Leslie A. Consitt, Jill A. Bell, Timothy R. Koves, Deborah M. Muoio, Matthew W. Hulver, Kimberly R. Haynie, G. Lynis Dohm, Joseph A. Houmard

Diabetes · 2010 · 60 citations · 32 references

DOIFull text

Open access

Abstract

Reduced mitochondrial content is related to impaired FAO in HSkMC derived from obese individuals. Increasing PGC-1alpha protein levels did not correct the obesity-related absolute reduction in FAO or mtDNA content, implicating mechanisms other than PGC-1alpha abundance.

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