Concepedia

Tissue-Specific Liver X Receptor Activation Promotes Macrophage Reverse Cholesterol Transport In Vivo

Tomoyuki Yasuda, Didier Grillot, Jeffery T. Billheimer, François Briand, Philippe Delerive, Stéphane Huet, Daniel J. Rader

Arteriosclerosis Thrombosis and Vascular Biology · 2010 · 135 citations · 17 references

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Abstract

We demonstrate that intestinal-specific LXR agonism promotes macrophage RCT in vivo and that macrophage LXR itself plays an important, but not predominant, role in promoting RCT in response to an LXR agonist.

References

17

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Joyce J. Repa, Guosheng Liang, Jiafu Ou et al. · Genes & Development · 2000 · 1.7K citations · Full text

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Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXRα

Asha Venkateswaran, Bryan Laffitte, Sean B. Joseph et al. · Proceedings of the National Academy of Sciences · 2000 · 990 citations

Regulation of ATP-binding Cassette Sterol Transporters ABCG5 and ABCG8 by the Liver X Receptors α and β

Joyce J. Repa, Knut Erik Berge, Chris Pomajzl et al. · Journal of Biological Chemistry · 2002 · 839 citations · Full text

The role of reverse cholesterol transport in animals and humans and relationship to atherosclerosis

Daniel J. Rader, Eric T. Alexander, Ginny L. Weibel et al. · Journal of Lipid Research · 2008 · 593 citations · Full text

Macrophage ABCA1 and ABCG1, but not SR-BI, promote macrophage reverse cholesterol transport in vivo

Xun Wang, Heidi L. Collins, Mollie Ranalletta et al. · Journal of Clinical Investigation · 2007 · 579 citations · Full text

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