Concepedia

Publication | Closed Access

Preclinical Testing of Clinically Applicable Strategies for Overcoming Trastuzumab Resistance Caused by PTEN Deficiency

DOI

194

Citations

27

References

2007

Year

Chien‐Hsing Lu, Shannon L. Wyszomierski, Ling‐Ming Tseng, Meng-Hong Sun, Keng‐Hsueh Lan, Christopher L. Neal, Gordon B. Mills, Gabriel N. Hortobágyi, Francisco J. Esteva, Dihua Yu
Clinical Cancer Research

Abstract

Combining trastuzumab with inhibitors of the Akt/mTOR pathway is a clinically applicable strategy and combinations of trastuzumab with triciribine or RAD001 are promising regimens for rescue of trastuzumab resistance caused by PTEN loss.

References

YearCitations

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